Publications

Research supported by Knight Initiative for Brain Resilience grants and fellowships is advancing our understanding of healthy brain aging and new approaches to combat neurodegenerative disease.

Alzheimer's & Dementia PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice

Tao Yang, Hasi Huhe, Sean-Paul Williams, Sukhneet Kaur, Yeonglong Albert Ay, Zachary W Davis-Gilbert, Gregory A Cary, Carolyn Paisie, Robert R Butler, Jesse Wiley, Ranjita Betarbet, Haian Fu, Duc Duong, Nicholas T Seyfried, Karina Leal, Gregory W Carter, Aled Edwards, Allan I Levey, Jacob L Capener, David H Drewry, Mohammad A Hossain, Hans J Oh, Alison D Axtman, Stacey J Sukoff Rizzo, Frank M Longo, Emory‐Sage‐SGC‐Jax TREAT‐AD Center
Date

Dec 26 2025
Alzheimer's & dementia Divergent trajectories of brain ageing across the seventh decade predict AD pathology in a UK population-based birth cohort

James Groves, Hamilton Se-Hwee Oh, Amelia Farinas, Veronica Augustina Bot, Dylan M Williams, Andrew Wong, William Coath, Ashvini Keshavan, Patricia Moran-Losada, Sarah-Naomi James, Marcus Richards, Jennifer M Nicholas, Alina Isakova, Tony Wyss-Coray, Jonathan M Schott
Date

Dec 24 2025
Alzheimer's & dementia Multimodal predictors of cross-sectional and longitudinal memory in a cognitively unimpaired aging cohort

Alexandra N Trelle, Jintao Sheng, Tammy T Tran, Ted N Wilson, Isha Sai, America Romero, Jennifer Park, Lucah Medina Guerra, Gayle K Deutsch, Anthony D Wagner, Elizabeth C Mormino
Date

Dec 23 2025
Alzheimer's & dementia Association of types of cognitive and social activities with cognitive performance and Alzheimer's disease biofluid biomarkers: an examination of cognitively normal adults in the Stanford Aging and Memory Study (SAMS)

Olivia Lu, Alexandra N Trelle, Christina B Young, Elizabeth C Mormino, Anthony D Wagner, Zihuai He, Valerie A Carr, Sharon J Sha, Hillary Vossler, America Romero, Jennifer Park, Irina Anna Skylar-Scott
Date

Dec 23 2025
Alzheimer's & dementia Associations between proper name retrieval, associativememory, and regional tau accumulation in a normal aging cohort

Isha Sai, Alexandra N Trelle, Jintao Sheng, Christina B Young, Kyan Younes, Jennifer Park, Lucah Medina Guerra, America Romero, Hillary Vossler, Anthony D Wagner, Elizabeth C Mormino
Date

Dec 23 2025
medRxiv : the preprint server for health sciences Pulsatile Brain Motion as a Marker of Brain Aging and Dementia: Insights from 3D q-aMRI

Itamar Terem, Kyan Younes, Skylar Weiss, Andrew Dreisbach, Hillary Vossler, Eryn Kwon, Daniel Cornfeld, Jet Wright, Paul Condron, Kathleen L Poston, Victor W Henderson, Elizabeth C Mormino, Samantha Holdsworth, Kawin Setsompop
Date

Dec 18 2025
Cell The effect of shingles vaccination at different stages of the dementia disease course

Min Xie, Markus Eyting, Christian Bommer, Haroon Ahmed, Pascal Geldsetzer
Date

Dec 3 2025
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bioRxiv : the preprint server for biology Life-long behavioral screen reveals an architecture of vertebrate aging

Claire N Bedbrook, Ravi D Nath, Libby Zhang, Scott W Linderman, Anne Brunet, Karl Deisseroth
Date

Dec 3 2025
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Cell reports Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging

Andy P Tsai, Douglas E Henze, Eduardo Ramirez Lopez, James Haberberger, Chuanpeng Dong, Nannan Lu, Micaiah Atkins, Emma K Costa, Amelia Farinas, Hamilton Se-Hwee Oh, Patricia Moran-Losada, Yann Le Guen, Alina Isakova, Stephen R Quake, Tony Wyss-Coray
Date

Nov 27 2025
medRxiv : the preprint server for health sciences Long-read genome sequencing and multi-omics in aging and neurodegeneration

Tanner D Jensen, Yann Le Guen, Lia Talozzi, Sherry Yang, John Gorzynski, Andrés Peña-Tauber, Ilaria Stewart, Alexis Ferrasse, Daniel Nachun, Maggie T Arriaga, Justin Lee, Rafael Catoia Pulgrossi, Junyoung Park, Jingyu Zhang, Anthony D Wagner, Elizabeth C Mormino, Kathleen L Poston, Victor W Henderson, Zihuai He, Tony Wyss-Coray, Stephen B Montgomery, Euan A Ashley, Michael D Greicius
Date

Nov 24 2025