Publications

Research supported by Knight Initiative for Brain Resilience grants and fellowships is advancing our understanding of healthy brain aging and new approaches to combat neurodegenerative disease.

Alzheimer's & Dementia Effects of α-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging

Joseph R Winer, Melanie J Plastini, America Romero, Hillary Vossler, Isha Sai, Divya Channappa, Carla Abdelnour, Marian Shahid-Besanti, Edward N Wilson, Hamilton Se-Hwee Oh, Christina B Young, Alexandra Trelle, Maya Yutsis, Sharon J Sha, Veronica Ramirez, Ryan Taylor, Kyan Younes, Tony Wyss-Coray, Michael D Greicius, Victor W Henderson, Anthony D Wagner, Kathleen L Poston, Elizabeth C Mormino
Date

May 3 2026
medRxiv (preprint – not peer reviewed) Plasma proteomics of _APOE_ genotype: age-specific analyses in UK population-based cohorts

Amy Packer, Tahsina Khatun, James W Groves, Tony Wyss-Coray, Jonathan M Schott, Petroula Proitsi, Emma L Anderson, Dylan M Williams
Date

May 1 2026
Molecular Neurodegeneration Plasma proteomic signatures of preclinical Alzheimer's disease in clinically unimpaired older adults

Alexandra N Trelle, Karly A Cody, Tran T Nguyen, Joseph R Winer, Skylar Weiss, Isha Sai, Tyler Ward, Gloria Cheng, Divya Channappa, Justin Mendiola, Amal Al-Rajhi, Keerthana Raghuraman, Sharon J Sha, Edward N Wilson, Tony Wyss-Coray, Holden T Maecker, Anthony D Wagner, Elizabeth C Mormino
Date

Apr 24 2026
Nature Communications Multiomics characterization of acute child illness and mortality in Africa and South Asia

Camilo A Espinosa, James M Njunge, Kirkby D Tickell, Abdoulaye Hama Diallo, Abu Sadat Mohammad Sayeem Bin Shahid, Md Amran Gazi, Zaubina Kazi, Emily Yoshioka, Caroline Tigoi, Moses Mburu, Moses Ngari, Narshion Ngao, Elisha Omer, Wilson Gumbi, Bonface M Gichuki, Anna Mitchel, Jessica Williams, Joseph Gogain, Nebojsa Janjic, Rupasri Mandal, Benjamin Jenkins, Hilary P Browne, Yan Shao, Timothy Rozday, Mark D Stares, Nicholas J R Dawson, Eloise Berson, Alan Chang, Yeasul Kim, Samson J Mataraso, Chi-Hung Shu, Thanaphong Phongpreecha, Lei Xue, Ali Saleem, Benson Singa, Tahmeed Ahmed, Wieger P Voskuijl, David S Wishart, Eric R Houpt, Jie Liu, Asad Ali, Ezekiel Mupere, Mohammod Jobayer Chisti, Robert H J Bandsma, Trevor D Lawley, Albert Koulman, Christina L Lancioni, Nima Aghaeepour, James A Berkley, Judd L Walson, Childhood Acute Illness and Nutrition (CHAIN) Network
Date

Apr 13 2026
Alzheimer's Research & Therapy Continuum of Core 1 biomarkers in preclinical Alzheimer's disease

Leonardino A Digma, Christina B Young, Joseph R Winer, Karly A Cody, Kyan Younes, Jintao Sheng, Philip S Insel, Robert A Rissman, Reisa Sperling, Elizabeth C Mormino
Date

Apr 10 2026
NPJ Parkinson's Disease Plasma phosphorylated tau 217 detects amyloid-β in neuronal synuclein disease

Alena M Smith, Sara A Lorkiewicz, Burak Arslan, Laia Montoliu-Gaya, Nicholas J Ashton, Edward N Wilson, Daniel Alcolea, Íñigo Rodríguez-Baz, Juan Fortea, Christina B Young, Joseph R Winer, Marian Shahid-Besanti, Hillary Vossler, Melanie J Plastini, Tianyu Pan, Elena Vera-Campuzano, Isabel Sala, Justin H Mendiola, Veronica Ramirez, Geoffrey A Kerchner, Katrin I Andreasson, Victor W Henderson, Thomas J Montine, Lu Tian, Elizabeth C Mormino, Henrik Zetterberg, Kathleen L Poston, Carla Abdelnour
Date

Apr 10 2026
bioRxiv (preprint – not peer reviewed) Mucin-binding protein shuttles enable delivery of brain-targeted therapeutics

Sophia M Shi, Gabrielle S Tender, Jian Xiong, Josephine K Buff, Hannah I Park, Justin H Mendiola, Edward N Wilson, Monther Abu-Remaileh, Carolyn R Bertozzi, Tony Wyss-Coray
Date

Apr 3 2026
medRxiv (preprint – not peer reviewed) Plasma pTau217 as a Prognostic, Monitoring, and Risk-Stratification Biomarker of Clinical Progression in Lewy Body Disease

S A Lorkiewicz, C Abdelnour, M Bolen, A M Smith, M Shahid-Besanti, D Hemachandra, E M Müller-Oehring, N Siddiqui, L Montoliu-Gaya, B Arslan, N J Ashton, E N Wilson, L Tian, K I Andreasson, E C Mormino, V W Henderson, H Zetterberg, K L Poston
Date

Apr 3 2026
bioRxiv (preprint – not peer reviewed) Granulin loss and TMEM106B risk converge on lysosomal C-terminal fragment pathology in frontotemporal dementia

Yi Zeng, Jian Xiong, Anastasiia Lovchykova, Thao Phuong Nguyen, Abigail Song, Semma W Gitler, Monther Abu-Remaileh, Aaron D Gitler
Date

Apr 3 2026
Nature Biotechnology Scalable single-cell total RNA sequencing unifies coding and noncoding transcriptomics

Alina Isakova, Daniel Dan Liu, Ivana Cvijović, Rahul Sinha, Anna E Eastman, Sirle Saul, Angela M Detweiler, Norma Neff, Shirit Einav, Irving L Weissman, Stephen R Quake
Date

Apr 1 2026