Publications

Research supported by Knight Initiative for Brain Resilience grants and fellowships is advancing our understanding of healthy brain aging and new approaches to combat neurodegenerative disease.

Neuron Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases

Muhammad Ali, Jigyasha Timsina, Ying Xu, Yike Chen, Katherine Gong, Daniel Western, Gyujin Heo, Menghan Liu, John Budde, Cyril Pottier, Suzanne E Schindler, John C Morris, David M Holtzman, Raquel Puerta, Amanda Cano, Merce Boada, Maria V Fernandez, Agustin Ruiz, Miquel Aguilar, Ignacio Alvarez, Pau Pastor, Joel S Perlmutter, Meghan C Campbell, Paul T Kotzbauer, Hamilton Se-Hwee Oh, Edward N Wilson, Yann Le Guen, Knight Alzheimer Disease Research Center (Knight-ADRC), Alzheimer Disease Neuroimaging Initiative (ADNI), Fundació ACE Alzheimer Center Barcelona (FACE), Barcelona-1, Stanford Alzheimer Disease Research Center (Stanford-ADRC), Global Neurodegeneration Proteomics Consortium (GNPC), Rawan Tarawneh, Tony Wyss-Coray, Yun Ju Sung, Laura Ibanez, Carlos Cruchaga
Date

Mar 31 2026
Molecular Neurodegeneration PLCG2 signaling and genetic resilience in Alzheimer's disease

Andy P Tsai, Amara K Martin, Andrew Mi, Ava E Yeh, Eduardo Ramirez Lopez, Tony Wyss-Coray
Date

Mar 27 2026
bioRxiv (preprint – not peer reviewed) Translational lipidomics reveals BMP and its precursor LPG as biomarkers for CLN5 Batten disease

Eshaan S Rawat, Nick Manfred, Hisham N Alsohybe, Wentao Dong, Isabelle V Peña, Maryam Idris, Christian Posern, Lena M Westermann, Samantha J Murray, Daan M Panneman, Stefania Della Vecchia, Stefano Doccini, Maria Marchese, Filippo M Santorelli, Peter M van Hasselt, Nadia L Mitchell, Angela Schulz, Monther Abu-Remaileh
Date

Mar 27 2026
Brain: a Journal of Neurology Longitudinal trajectories of divergent cortical tau patterns in preclinical Alzheimer's disease

Christina B Young, Jintao Sheng, Joseph R Winer, Karly Cody, Isha Sai, Mackenzie L Carlson, Kyan Younes, Philip S Insel, Aaron P Schultz, Elizabeth C Mormino
Date

Mar 26 2026
JCI Insight KIF5A downregulation in spinal muscular atrophy links axonal regeneration defects with ALS

Tetsuya Akiyama, Yi Zeng, Caiwei Guo, Olivia Gautier, Lauren Koepke, Heankel Lyons, Elana Molotsky, Juliane S Bombosch, Odilia Sianto, Jay P Ross, Phuong Hoang, Luke Zhao, Cole Spencer, Charlotte J Sumner, Michelle Monje, John W Day, Aaron D Gitler
Date

Mar 26 2026
bioRxiv (preprint – not peer reviewed) Abnormal enteric nervous system organization and gastrointestinal motility in mice with valproic acid-induced neural tube defects

Gabrielle R Barsh, Kelbi Banducci, Julia A Kaltschmidt
Date

Mar 23 2026
Nature Metabolism Python metabolomics uncovers a conserved postprandial metabolite and gut-brain feeding pathway

Shuke Xiao, Mengjie Wang, Thomas G Martin, Barry Scott, Xing Fang, Xinming Liu, Yongjie Yang, Sipei Fu, Steven D Truong, Jack F Gugel, Gregory L Maas, Marcus P Mullen, Jennifer Hampton Hill, Veronica L Li, Andrew L Markhard, Mingming Zhao, Wei Qi, Saranya C Reghupaty, Meng Zhao, Jan Spaas, Wei Wei, Trine Moholdt, John A Hawley, Christian T Voldstedlund, Erik A Richter, Xiaoke Chen, Katrin J Svensson, Daniel Bernstein, Leslie A Leinwand, Yong Xu, Jonathan Z Long
Date

Mar 20 2026
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Nature Reviews Molecular and Cell Biology Technologies to measure and modulate protein subcellular localization

William Leineweber, Reika Tei, Anna Mäkiniemi, Alice Ting, Emma Lundberg
Date

Mar 20 2026
Nature Methods CellVoyager: AI CompBio agent generates new insights by autonomously analyzing biological data

Samuel Alber, Bowen Chen, Eric Sun, Alina Isakova, Aaron J Wilk, James Zou
Date

Mar 18 2026
Science Lifelong behavioral screen reveals an architecture of vertebrate aging

Claire N Bedbrook, Ravi D Nath, Libby Zhang, Scott W Linderman, Anne Brunet, Karl Deisseroth
Date

Mar 12 2026
Related Project

Predicting and promoting resilient brain aging trajectories
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