Plasma proteomic signatures of preclinical Alzheimer's disease biomarkers and memory in clinically unimpaired older adults

medRxiv : the preprint server for health sciences |

Alexandra N Trelle, Karly A Cody, Tran T Nguyen, Joseph R Winer, Skylar Weiss, Isha Sai, Divya Channappa, Justin Mendiola, Amal Al-Rajhi, Keerthana Raghuraman, Sharon J Sha, Edward N Wilson, Tony Wyss-Coray, Anthony D Wagner, Holden T Maecker, Elizabeth C Mormino

BACKGROUND: Multianalyte plasma proteomic panels that can accurately detect initial AD pathology in preclinical populations and simultaneously measure related biological processes relevant for disease risk are critical for advancing early detection and prognosis.